Chronoregulation by Asparagine Deamidation
نویسندگان
چکیده
منابع مشابه
Cxvi. the Enzymic Deamidation of Asparagine
THE occurrence of asparagine in the higher plant and its role in protein metabolism have formed the subject of numerous investigations. It has been found that the amount normally present in the green plant is very small and it is only under artificial conditions, associated with a carbohydrate deficiency, that an accumulation of this substance is ever obtained. E. Schulze [1906], in a series of...
متن کاملTransamination and associated deamidation of asparagine and glutamine.
With this system, no deamidation of glutamine occurred in the absence of a-keto acid, and, with all keto acids tested except two (pyruvate and a-ketobutyrate), transamination was absent or extremely slow when glutamate was substituted for glutamine. Experiments with W-labeled glutamine indicated that the ammonia evolved during this reaction was derived from t.he amide group of glutamine. Althou...
متن کاملAsparagine deamidation and the role of higher order protein structure.
The 'protein world' exhibits additional complexity caused by post-translational modifications. One such process is nonenzymic deamidation of asparagine which is controlled partly by primary sequence, but also higher order protein structure. We have studied the deamidation of an N-terminal peptide in muscle glyceraldehyde 3-phosphate dehydrogenase to relate three-dimensional structure, proteolys...
متن کاملAn antigenic peptide produced by reverse splicing and double asparagine deamidation.
A variety of unconventional translational and posttranslational mechanisms contribute to the production of antigenic peptides, thereby increasing the diversity of the peptide repertoire presented by MHC class I molecules. Here, we describe a class I-restricted peptide that combines several posttranslational modifications. It is derived from tyrosinase and recognized by tumor-infiltrating lympho...
متن کاملDeamidation reactions of protonated asparagine and glutamine investigated by ion spectroscopy.
RATIONALE Deamidation of Asn and Gln residues is a primary route for spontaneous post-translational protein modification. Several structures have been proposed for the deamidation products of the protonated amino acids. Here we verify these structures by ion spectroscopy, as well as the structures of parallel and sequential fragmentation products. METHODS Infrared ion spectroscopy using the f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science's STKE
سال: 2007
ISSN: 1525-8882
DOI: 10.1126/stke.4092007re7